With City playing in the early evening kickoff, Arsenal will want to put the pressure on their title rivals by getting another win on the board against Leicester on Saturday.
Aaron Ramsdale will start in goal, with Ben White and Oleksandr Zinchenko expected to be selected in the two fullback positions.
Despite some shaky moments against Aston Villa, William Saliba will continue to partner Gabriel in the centre of defence.
There could, though, be a change in the middle of the park. Manager Mikel Arteta has hinted that Thomas Partey has a chance of starting after missing the last two matches with a back problem.
That means Jorginho could drop out, with Granit Xhaka and captain Martin Odegaard making up the rest of the midfield three.
Up front, Gabriel Martinelli’s goal at Villa Park could be enough for him to be recalled to the starting lineup, with Leandro Trossard making way. Eddie Nketiah and Bukayo Saka are likely to keep their places.
Arsenal’s Predicted XI To Face Leicester:
Ramsdale, White, Saliba, Gabriel, Zinchenko, Partey, Odegaard, Xhaka, Saka, Nketiah, Martinelli